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Why CBD Oil Potency Matters – And 5 Of The Strongest CBD Oils

From a consumer’s perspective, potency is one of the most important things to consider when purchasing a CBD oil. There are many factors that distinguish one CBD oil from the next, but strength is the kicker, determining everything from the cost of a product to its ultimate therapeutic effectiveness. Yet such an important element is often misunderstood.

The strength of a CBD oil definitely depends on how much cannabidiol it contains. But other elements play important roles in the potency equation, too. How do you measure the strength of a CBD oil? Does strength really matter as much as everyone seems to think it does? And what exactly is CBD oil in the first place? In this guide, we dive into all of those questions and more, closing with a list of the five strongest CBD oils on the market.

Learn all about what makes a CBD oil strong, what experts consider “high potency,” and get answers to common questions and concerns about buying CBD oils, so you can make the best product choice for your health and wellness needs.

What is CBD Oil?

Let’s start with the basics. What exactly is CBD oil? The simplest answer is that CBD oil is a liquid product that consists of the cannabinoid cannabidiol (CBD) infused in a fatty carrier oil. Carrier oils are typically medium-chain triglycerides (MCTs) such as coconut oil, that are easy to digest and linked to many health benefits. Carrier oils can also be extra virgin olive oil, grapeseed oil, or as is commonly found in hemp-derived products, cold-pressed hemp seed oil.

At minimum, CBD oil consists of these two essential ingredients: cannabidiol and a carrier oil. But most products contain much more. Depending on the source of the CBD and how it gets extracted, concentrated, and processed, CBD oils can contain other cannabinoids such as THC and plant compounds including terpenes, flavonoids and other phytonutrients. The carrier oil can also add other ingredients to the oil, especially if derived from hemp or cannabis. Finally, some manufacturers might add aromatic ingredients such as essential oils to their finished products.

As a result of all these variables, CBD oils can vary dramatically in color, consistency, and flavor, even before taking strength into account. And strength largely depends on how a CBD oil is formulated. At one end of the spectrum, there’s CBD isolate, the strongest and purest form of CBD available. Using solvents or supercritical gases, manufacturers extract cannabidiol from every part of the hemp plant, producing a crystalized form of CBD that’s typically above 99% pure. CBD isolate isn’t an oil, per se. Instead, manufacturers suspend it in a carrier oil until it reaches the desired concentration.

Cannabidiol (CBD) oil can be sourced from hemp or marijuana plants. The difference is hemp-derived CBD contains 0.3% or less THC, while marijuana-derived CBD contains more and can only be purchased and used where marijuana is legal. (Photo by Shutterstock)

At the other end of the spectrum, there’s broad-spectrum or full-spectrum CBD oil. Typically, though not necessarily, sourced from hemp plants, broad-spectrum CBD oils have been minimally processed and purified. As a result, they contain the widest range of minor cannabinoids, nutrients, vitamins, terpenes and more.

In the middle of isolate-based oils and full-spectrum oils, you’ll find CBD distillates. Less refined than isolates, distillates contain more of the source plants’ cannabinoids, terpenes, flavonoids and other compounds. But they’re more refined than broad-spectrum oils. Distillates are more common in states with legal cannabis markets, since they usually contain more THC than the 0.3% limit set by federal law with the signing of the 2018 Farm Bill.

The boundaries between isolates, distillates and full-spectrum CBD oils aren’t always so clear. For example, a strong CBD oil made with a 99.7% pure isolate may also contain a range of minor cannabinoids and terpenes because it uses a broad-spectrum hemp seed oil as a carrier.

How Is Strength Determined?

At first glance, measuring the strength of a CBD oil seems simple. Read the label to see how much CBD a product contains, and voila. But because CBD oils can be isolates, distillates, or broad-spectrum, determining strength can be a bit tricky. Moreover, some product labels can make it harder to know exactly how strong a product is, or how potent a dose it provides. So we’ll start there, with the product label of a CBD oil itself. Then, we’ll take a look at how testing labs measure the strength of a CBD oil, and how that connects with what’s on the label.

“When you’re talking about strength, you’re talking about potency,” explained Adie Rae, a science adviser to Weedmaps News and an academic researcher with a Ph.D. in neuroscience who has been studying cannabinoids since 2004. “And that means how much CBD per volume.”

As Rae explained, you could have two CBD oils, both in 30 milliliter bottles. But one contains 3,000 milligrams of CBD and the other contains 6,000 milligrams of CBD. In this example, the stronger oil is the one with 6,000 milligrams of CBD per 30 milliliter container. In fact, it’s twice as strong, so you’d have to take twice as much of the less potent oil to achieve the same dose. And if the stronger CBD oil is less than twice as much as the weaker version, you’re saving yourself money by going with the more potent bottle.

Makers of cannabidiol (CBD) oils have not settled on a standard measurement for concentration. Some labels will list purity, while others will list percentage by volume (Photo by Shutterstock)

Sometimes, however, packages will tell you what percentage of CBD contained in the oil. This is where things can get confusing. A label may say that the CBD in the product is 99% pure if it contains a CBD isolate, or 70% if it contains a distillate. This tells you the strength of the CBD in the oil, but it doesn’t tell you how potent the CBD oil is by volume. And that means you won’t be able to tell how strong a dose is, so it’s important to find where the package indicates how much CBD it contains in milligrams.

From a lab technician’s perspective, however, determining CBD oil strength looks a little different. According to Myron Ronay, CEO of BelCosta Labs, manufacturers test for strength at every stage of the supply chain. They test the industrial hemp plants for CBD potency, then the initial “crude” oil and again at each stage of distillation. CBD oil manufacturers do this to ensure quality, consistency and legal compliance. But it’s a test of the final product that determines what gets printed on the label.

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Most of the time, labs like BelCosta use High Performance Liquid Chromatography (HPLC) to measure CBD oil strength. For the technically curious, the test produces a table of wavelengths that act as the chemical fingerprints of various cannabinoids. This allows lab technicians to identify which compounds a sample contains as well as their relative quantities.

When testing for CBD oil strength, BelCosta analyzes for 14 different major and minor cannabinoids, including CBD, tetrahydrocannabinol (THC), cannabinol (CBN), and cannabigerol (CBG). The results show the percentage of CBD and other compounds in the sample. Reliable CBD oil companies will provide these results on their websites or product packaging.

Does Strength Matter?

Undeniably, today’s CBD market places a premium on potency. But does strength matter? And if so, how much? The truth is, we still really don’t know. When it comes to CBD, nothing is standardized. A dose that works for one person might be totally ineffective for someone else. Our individual bodies and metabolism, the bioavailability of different consumption methods and myriad other factors make experiences with CBD highly subjective and variable. Still, CBD consumers aren’t completely in the dark. Strength does matter, and in a few very important ways.

First, strength matters from the standpoint of efficacy. The stronger a CBD oil, the higher its potency, the more effects it’s going to produce. So what counts as a strong CBD oil? In the view of Rae, the cutoff for a “high potency” CBD oil is 35 milligrams per serving. Anything below that, and consumers are likely to have immeasurable blood levels of CBD.

“For me, when I’m buying hemp oil, I go for 50 milligrams CBD per milliliter,” Rae said. That’s a fairly high concentration of CBD, and one you won’t find in most CBD oil products below the $100 mark.

But potency (mg/mL) is only part of the larger strength equals efficacy equation. Research is still ongoing, but most experts agree that CBD on its own is going to be less effective overall than a full-spectrum oil containing roughly the same amount of CBD.

“No matter how much CBD isolate you’re taking, it’s not going to be as therapeutically beneficial as a broad-spectrum product,” Rae said.

BelCosta Lab’s Myron Ronay echoes Rae’s preference for broad-spectrum CBD oil over isolates. He said CBD is most effective when it can take advantage of the entourage effect, which is its interaction with other cannabinoids and terpenes in the oil.

To bind with the cell receptors of the human endocannabinoid system (ECS) and therefore produce therapeutic effects, CBD might need the help of THC and minor cannabinoids such as CBG, CBN, tetrahydrocannabivarin (THCV) and others. “Ratio is more important than strength in absolute terms,” Ronay said. “A little bit of THC goes a long way,” Rae said.

And that’s usually the difference between a broad-spectrum and a full-spectrum” product: full-spectrum cannabis oil contains THC. (Look out, though, for the word “full-spectrum” on products sourced from hemp; these have less than .3% THC in raw form). But outside of licensed medical or recreational cannabis dispensaries, CBD products have to contain less than 0.3% THC to remain legal. This makes it difficult to find products containing therapeutic levels of THC in states without legalized cannabis.

For consumers without access to legal cannabis shops, broad-spectrum products (without the THC) are the next best thing, because they often combine high-strength isolate or distillate with broad-spectrum hemp oil. In short, you should ultimately choose a strong CBD oil that contains the most ingredients possible.

Swallowing cannabidiol (CBD) oil reduces most of its effectiveness. The bioavailability, or the ability of CBD to reach the bloodstream and produce its therapeutic effects, is around 5%. (Photo by Shutterstock)

Rae has some more crucial advice for CBD oil consumers looking for strength. Don’t swallow it! Studies have shown that the oral bioavailability of CBD is shockingly low, at just around 5%. In other words, only a fraction of the CBD oil you swallow is making it into your bloodstream where it can produce therapeutic results. But as Rae explained, there are a couple ways to hack CBD’s low bioavailability.

First, keep the oil under your tongue for as long as possible; try to make it to 4 or 5 minutes. “This method treats the oil more like a topical than an edible, and keeps the CBD safe from the digestive enzymes that break it down,” Rae said.

Second, if you do have to swallow the oil, take it at the same time as some black pepper. Piperine is a molecule in black pepper that shuts down the drug-metabolizing enzymes in your liver, giving CBD a better chance of getting absorbed.

Finally, no discussion of the importance of CBD oil strength would be complete without tackling the issue of product safety. It’s important to keep in mind that outside of licensed dispensaries, CBD products are still unregulated. There’s no real rules yet for acceptable levels of pesticides, chemical fertilizers, heavy metals and other contaminants. Screening for them isn’t required, and there are no restrictions on selling products that contain them. The only thing that matters is staying below the 0.3% THC threshold.

High-potency CBD oils in particular amplify concerns about contamination. As Ronay explained, concentrating for potency involves concentrating everything else in and on the hemp plant, too. “How do you know what’s in it or what’s safe? People are looking for a cure and for health and facing the unknown,” Ronay said.

But you don’t have to face the unknown. Here are five of the strongest CBD oils on the market, selected based on their potency, efficacy and how transparent the company is with what’s inside the bottle. Keep in mind, strength is all relative. What matters is potency: how much CBD a single dose provides, whether it’s a drop or a full milliliter dropper.

The oils below are all CBD-heavy, at concentrations way above the average product, with prices to match. We favored broad-spectrum oils due to their added therapeutic benefits. And remember, if you want to make your CBD oil stronger, all you need to do is take more of it!

5 of the Strongest CBD Oils on the Market

MyNaturalCBD — 5,000 milligrams Full-Spectrum Hemp Oil Tincture (30 milliliters)

Some oils you take by the dropper. This one, you take by the drop. At 5,000 milligrams of CBD, you’d be hard pressed to find a stronger CBD oil at the 30 milliliter level. Lab results indicate an even higher 5,280 milligrams of CBD, along with trace (and legal) percentages of THC, cannabidiolic acid (CBDA) and CBG. And to make way for all that cannabidiol, MyNaturalCBD uses a simple formula. This product fuses high-potency CBD with a blend of full-spectrum hemp oil and MCT oil from coconuts.

A high-potency CBD oil like this allows you to fine-tune your dosage. Each drop contains a little more than 8 milligrams of CBD. With four or five drops, and you’ve reached that 35-milligram-per-dose benchmark. A 0.5 milliliter dose would deliver 84 milligrams of CBD.

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Availability: United States

Cannabidiol Life — 6,000 milligrams Whole Plant Hemp Extract CBD Oil (120 milliliters)

Cannabidiol Life’s most potent offering is a perfect example of why it’s important to measure a CBD oil’s strength by volume. At 3,000 milligrams CBD, this whole plant hemp extract oil contains more cannabidiol than most products on the market. But its potency isn’t as extreme as it may appear. This is a 60 milliliter bottle, putting CBD potency at a humbler 50 mg/mL — therapeutically beneficial, but not chart-topping. Still, because Cannabidiol Life contains so much CBD, you can easily obtain 75–100 mg/mL doses, or higher, if required.

Enjoyable CBD — 3,000 milligram Full-Spectrum CBD Tincture (30 milliliters)

Enjoyable CBD’s full-spectrum CBD tincture clocks in at 100 mg/mL. And while that may not be the strongest CBD oil on the market by the numbers, it’s one of the strongest in terms of how much CBD gets into your bloodstream. That’s because this CBD is all about bioavailability. Enjoyable CBD uses full-spectrum Imperial CBD Oil, a formula which uses molecular encapsulated CBD to help improve how well your body absorbs the cannabidiol.

The unique extraction and distillation process produces a completely THC-free oil, however, so this is a case where strength may require a trade-off with the benefits of the entourage effect.

Availability: United States

Green Roads — 3,500 milligrams Pharmacist Formulated CBD Oil (60 milliliters)

Green Roads is a prominent name in CBD products, and its 3,500 milligram CBD oil is its flagship product. Each milliliter of this formula delivers 66.36 milligrams of hemp-derived CBD, according to the most recent lab sheets — stronger than advertised. Green Roads’ formulates this broad-spectrum CBD oil with a proprietary blend of terpenes, sourced from hemp seed oil.

Consumers can take confidence in the clear and regularly updated lab sheets provided about this and all Green Roads products. And Green Roads isn’t just testing for CBD. It also screens for pesticides, solvents, heavy metals, microbials and other contaminants and only sells products from batches that pass all tests.

Availability: United States

Hempassion — 4,000 milligrams Nature’s Nectar CBD Oil (10 milliliters)

This is a 10 milliliter bottle of CBD oil that contains 7.26 grams of cannabidiol in a 55 percent CBD distillate. Germinated hemp seed oil, this product’s carrier oil, adds even more CBD in addition to minor cannabinoids, terpenes and other hemp phytonutrients. Hempassion says germinated hemp seed oil is one of the most nutritionally balanced supplements currently known.

According to Hempassion, each milliliter of Nature’s Nectar CBD oil contains 20 drops, and each drop contains about 20 milligrams of cannabidiol. Two or three drops under the tongue is all you need for a therapeutically significant dose of this ultra-high potency CBD oil. This is a product that highlights the cost savings of purchasing more concentrated CBD oils.

Availability: United Kingdom, United States

Featured Image: With so many cannabidiol (CBD) oil makers on the market offering a variety of hemp-derived and marijuana-derived products in a vast array of purity levels and strengths, what’s a consumer to do? For starters, look for CBD strength by volume. (Gina Coleman/Weedmaps)

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Clean and Complete Full Spectrum CBD Oil with less than 0.3 THC.

Our Full Spectrum CBD Oil with less than .3 THC is 100% natural and enriched with phytocannabinoids, terpenes, and a pleasant, light, citrus flavor. A scientifically formulated product that combines the full power of CBD with THC while containing no added sugars, stevia, or artificial sweeteners.

This formula has been lab-tested for potency and safety. Our Full Spectrum CBD Oil contains less than 0.3 THC, which adheres to the legal guidelines set for maximum THC content. If you need something 100% free of THC, see our Full Spectrum with zero THC line (click here).

Our Full Spectrum CBD oil with less than 0.3 THC is offered in various dosages. For example, you can choose 500 mg or 1,000 mg.

As numerous research studies are conducted on CBD, our products are continuously a reliable source of high-quality CBD that is accountable and beneficial.

For more information on CBD and its properties, read US Patent A6630507.

The Trusted Lab Full Spectrum CBD with less than 0.3 THC and all our products are attractive in several sensory elements, such as taste and small. It is an enjoyable product with guaranteed high quality.

The Benefits

Our Full Spectrum CBD oil is a powerful blend of cannabinoids, terpenes, and 100% organic coconut oil created to help you during those long, hard days.

The Formula
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  • Ingredients: Full Spectrum CO2 extracted CBD oil, Naturally Occurring Therapeutic Terpenes, Organic MCT Coconut Oil, and Natural Citrus Flavor
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How To Use

Full Spectrum CBD oil: Fill dropper to desired amount. Dispense the oil under the tongue, and hold for 60 seconds. Allow the product to sit for these seconds before consuming it. The product is suitable to be used in daytime or nighttime. We recommend using one full dropper of oil twice a day and making modifications as needed for maximum results.

A 30 ml bottle will last approximately 30 days.

When To Use: Anytime

How Often: Daily

Absorption: Allow 15 minutes for maximum absorption. Please note this oil contains less than 0.3 THC, the maximum allowed by law. Trace amounts of THC may appear present in any drug testing that tests for THC.

Remember, CBD’s bio-availability is better if taken with food.

Always listen to how your body feels and adjust accordingly.

CBD Oil — Are the Benefits Claimed Too Good To Be True?

These days, many of us could certainly go for a miracle cure-all, especially those of us who struggle with chronic pain, overwhelming anxiety, cancer-related symptoms and/or hard-to-treat neurological disorders. So, it’s no wonder that CBD oil is popping up in our search results. But can we really count on CBD oil to positively impact our symptoms in the ways we hope? Internal medicine specialist Paul Terpeluk, DO, explains why CBD oil may not be as effective as we’d like.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

What is CBD?

CBD, or cannabidiol, is just one of more than 100 chemical compounds found in the cannabis sativa plant. But it’s THC (tetrahydrocannabinol), not CBD, that’s the main psychoactive compound in cannabis that gives you a euphoric high.

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CBD is pulled from hemp, a type of cannabis plant that contains very low levels of THC, so it doesn’t get you high. CBD oil is simply a product that contains CBD extract and an oil, like coconut oil, typically for topical use.

It’s important to know that since the implementation of the 2018 Farm Bill, the production and sale of CBD products in the U.S. has been legalized on the federal level as long as they contain less than .3% of THC. However, it’s still illegal under some state laws.

Plus, Dr. Terpeluk explains the market has been oversaturated with CBD products — from bath bombs to gummies, lotions, creams, tinctures and oil — none of which are Food and Drug Administration (FDA) approved and may not be 100% pure CBD. As of mid-December 2021, the FDA has only approved one cannabis-derived and three cannabis-related products, all of which you can safely get with a prescription from a licensed healthcare provider.

“There’s no oversight of the majority of CBD products from a regulatory authority,” says Dr. Terpeluk. “Most of the CBD that you’re buying, unless they have a rigorous marketing campaign and quality control that says it’s 100% CBD oil, more than likely, it’s contaminated with other cannabinoids, including THC.”

What are some of the benefits of CBD?

Several studies show the benefits of pure CBD may have wide-ranging positive effects, though. To understand those benefits, it’s important to consider our body’s endocannabinoid system, a complex system of enzymes, neurotransmitters and receptors that plays an important role in the development of our central nervous system. This system helps regulate a variety of functions, including pain, motor control, memory, appetite, inflammation and more. By further studying CBD’s effects in these specific areas, we may better understand how CBD impacts a variety of conditions and disorders.

Helps with neurological-related disorders

The FDA has approved Epidiolex as a treatment for several seizure disorders, including two rare disorders known as Duvet syndrome and Lennox-Gastaut syndrome. Several case studies suggest CBD may also be beneficial to patients who are resistant to anti-epileptic drugs. “With epilepsy, there’s a threshold in your brain that gets excitatory, and you go into a seizure,” says Dr. Terpeluk. “CBD increases that threshold.”

Other studies suggest CBD may also be useful in managing symptoms of multiple sclerosis, Parkinson’s disease and Alzheimer’s disease, as it has neuroprotective, anti-inflammatory properties. More studies are needed, however, as many suggest that it’s not just CBD alone, but a combination of CBD and other cannabinoids, that may help reduce many of these symptoms.

It may assist with pain relief

By interacting with neurotransmitters in your central nervous system, CBD could potentially relieve pain related to inflammation, arthritis and nerve damage (peripheral neuropathy). In one four-week trial, people who had nerve damage in the lower half of their body reported a significant reduction of intense, sharp pain after using a topical CBD oil.

“All of our different anti-pain drugs affect some section of our pain system, whether it’s Tylenol®, Aspirin®, morphine or opioids,” explains Dr. Terpeluk. “No one wants to be addicted to opioids, so if there’s a cannabinoid you can take that’s not addictive but can repress the pain, that would be the Holy Grail with chronic pain.”

Still, he cautions, there’s a lot left to be studied, including whether there are significant adverse long-term effects of CBD when used for pain relief.

“If you’re taking it in an unregulated fashion, you don’t know how much is in there, and you’re not quite sure how it affects you outside of your particular pain,” says Dr. Terpeluk.

It may help with anxiety and mood disorders

Anxiety and mood disorders like depression or post-traumatic stress disorder can have a severe effect on your daily life and may often cause both physical and emotional stress that could lead to other underlying conditions like sleep disorders, high blood pressure, chronic pain and heart disease. It’s too early to understand the full gamut of effects that CBD may have on anxiety and mood disorders, but individual studies seem to suggest varying positive results. In one study of 57 men who received either oral CBD or a placebo 90 minutes before participating in a simulated public speaking test, researchers learned that a 300-mg dose of CBD significantly reduced social anxiety during the test.

And while there are a wide variety of treatments available for anxiety and mood disorders — ranging from talk therapy and counseling to prescribed medications — Dr. Terpeluk suggests the most important thing is to get at the root of the underlying causes of the anxiety you’re experiencing.

“Anxiety is better approached by looking at what’s causing it in your life rather than trying to figure out which drugs can reduce it,” says Dr. Terpeluk.

It might help with cancer-related symptoms

CBD may help with nausea, vomiting and weight loss caused by chemotherapy treatments. The FDA has approved three cannabis-related products to help alleviate these symptoms, as well as help increase the appetite for those who have AIDS. These drugs all contain some level of THC or synthetic THC and are not purely CBD alone.

But some studies seem to suggest that CBD can help decrease the size of tumors and help stop the spread of cancerous cells in skin cancer, breast cancer, prostate cancer and more. As with other areas of study, further human clinical trials are needed to understand the full effect CBD has on various kinds of cancer.

What are the side effects or risks of CBD?

If you’re purchasing CBD oil and other products online or from a local vendor, Dr. Terpeluk says there’s no real way of knowing the purity of the CBD you’re using, as it could be mixed with other cannabinoids, such as the dangerous delta-8, or THC.

“It’s a little bit mysterious. It’s not as harmless as you think,” says Dr. Terpeluk. “If you take CBD oil because you buy it on the market, you have a very high likelihood that you could turn a drug test positive for THC because it could actually contain THC.”

CBD can also affect a variety of medications, including pain medications, antidepressants, antipsychotics and more. It could also cause several side effects that may include:

  • Issues with coordination. .
  • Drowsiness or fatigue. .

The best advice? Before considering CBD oil or other CBD products, make sure you talk to your healthcare provider to decide whether it’s safe for you and to ensure it doesn’t have harmful interactions with any medications you’re currently taking.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

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