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If you are keen on understanding more about CBD or CBD products, CALL The Hemp Doctor today to learn more. We will answer all of your questions. Water-Soluble vs. Oil-Soluble CBD : What You Need To Know Hemp-derived CBD oil has gone mainstream. CBD, also known as cannabidiol, is an incredibly beneficial plant compound derived from Hemp. Although not everyone knows about it yet, the vast majority of people out there that have heard about it associate it with oil A recent study by researchers affiliated with Colorado State University has found that water-soluble cannabidiol products provide the best absorption of CBD, shedding new light on best practices for consumers seeking the benefits of the popular cannabinoid.

Is Water-Soluble CBD Better Than CBD Oil?

One of the most popular groups of products on the market – and one that’s gaining traction like crazy – are those that contain CBD. CBD, also known as cannabidiol, is one of over 100 chemical compounds (referred to as cannabinoids) that comes from cannabis plants.

They can be used for many different purposes, they come in many forms, and they’re completely safe for use.

But, as consumers decide how and when to incorporate CBD products into their daily routines, one aspect to consider is the two most popular forms that CBD can come in. Here, we’ll be focusing specifically on water-soluble CBD in comparison to CBD oil, the characteristics and uses of each, and how to determine which might be a better fit for your lifestyle needs.

What Is CBD Oil?

First, let’s talk about CBD oil. Without a doubt, it’s one of the more common CBD products you will see on the shelves these days, but equally as common are some of the misperceptions that surround it. Essentially, CBD oil is simply any product where its CBD component has been extracted from a cannabis plant, then added to an oil (such as coconut or hemp seed oil, for example) to be diluted.

What Are the Characteristics of CBD Oil?

Because CBD oil is an oil, just like any other, its characteristics are similar to those of other oil types. Though it contains CBD (which, you’ll recall, is a cannabinoid), CBD oil does not contain another well-known cannabinoid called tetrahydrocannabinol (THC). THC is the chemical compound responsible for the psychoactive effects of “getting high” that users often experience when using marijuana and other cannabis products. Because CBD oil does not contain THC, a key characteristic of CBD oil is its ability to transfer some of the benefits of cannabis, but without the psychoactive “high” sensation.

As an oil, consumers can use CBD oil in a variety of ways. Users can ingest CBD oil, apply it topically, or inhale it. But, given the physiological constraints that oil undergoes while being digested in our digestive systems, researchers have concluded that rubbing CBD oil directly onto the skin, dropping some under the tongue, or even vaping the oil can bypass these digestive blockages and allow all of the CBD and its benefits to enter the body’s circulation. If CBD oil is ingested normally, it’s estimated that only about 10 to 20 percent will actually reach the bloodstream.

What Is Water-Soluble CBD?

Like CBD oil, water-soluble CBD does not contain THC which, you’ll recall, is what produces the psychoactive “high” effects. But, unlike CBD oil, water-soluble CBD is a CBD extract that has been scientifically converted to a water-soluble form, making it much easier for the body to absorb.

What Are the Characteristics of Water-Soluble CBD?

CBD, a naturally oil-soluble substance, is converted into a water-soluble one by way of breaking down the oil into small particles then coating the particles with a bio-encapsulation that ensures the CBD is stabilized. In essence, what we are left with is a light, water-soluble, powdery CBD extract that can be fully digested and absorbed by the body.

What Are the Common Uses of Water-Soluble CBD?

Once CBD oil has been encapsulated to be made water-soluble, its uses can be expanded to nearly any product in which consumers want to include it. Because of its amazing potential to be fully absorbed in the body, water-soluble CBD gets more bang for its buck when added to drinks, foods, or other means of consumption. When water-soluble CBD is used in this capacity, there’s no fear of low CBD absorption levels, nor is there fear of psychoactive effects (since, again, water-soluble CBD does not contain THC).

When Is It Better to Use Water-Soluble CBD?

Though choosing between water-soluble CBD products and CBD oil products is obviously each individual’s choice, the key to deciding which could be right for you is by evaluating your priorities.

Do you like the taste of CBD oil? Do you like applying it topically to your skin as part of your care regimen? And how about vaping CBD oil – do you enjoy it? If so, continuing to use CBD oil as a means to glean its benefits, while also enjoying the product itself, is perfectly fine and recommended.

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If you’re not a strong fan of CBD oil’s taste, if you’re not interested in using it as a skin enhancer, or if you’re not interested in vaping the oil, water-soluble CBD is the better option to choose.

If you’re simply interested in getting the maximal results of CBD, without the psychoactive effects of THC, consider incorporating water-soluble CBD products into your diet.

In conclusion, is water-soluble CBD better than CBD oil? Though each individual’s CBD priorities will affect the answer to this question, there’s no denying that water-soluble CBD is more easily absorbed by the body through a wider variety of consumption methods.

But, the choice is yours.

How Do I Get the Most Out of My CBD?

If you are taking your CBD orally through a tincture, softgel, or edible the CBD is going to pass through your digestive tract before it gets to your bloodstream. This is why we suggest taking your oral CBD with or directly after a meal. By doing so, the processing of the CBD by your stomach and liver is slower than if you were to take it on an empty stomach.

By slowing the processing down the CBD and other cannabinoids, flavonoids, and terpenes that are contained in your product have more time to get into your bloodstream, thereby increasing their effectiveness. An additional note if you are ingesting CBD oil: because it is oil-soluble the best type of meal to eat before taking your CBD is one that is high in healthy fats, like fish or avocados. This not only slows the processing of the beneficial cannabinoids, but the fats will also help to break them down in order to get a higher absorption rate.

Another factor to getting the most out of your CBD is maintaining its potency with proper storage. Always keep the lid to your product tightly sealed when not in use, and store it in a cool, dry area away from direct sunlight.

Interested in Learning More about Which CBD Product Is Right for You?

If you’re interested in learning more about what you can expect from CBD oil and water-soluble CBD, look no further than The Hemp Doctor.

At The Hemp Doctor, our goal is to give customers accurate information on CBD and hemp products and to provide only the best, safest, and purest hemp and CBD products available on the market. If you’re interested in learning more about CBD products, how water-soluble CBD differs from CBD oil, and how you can use both in a variety of ways, contact us online today.

Water-Soluble vs. Oil-Soluble CBD : What You Need To Know

CBD, also known as cannabidiol, is an incredibly beneficial plant compound derived from Hemp. Although not everyone knows about it yet, the vast majority of people out there that have heard about it associate it with oil. They may imagine any of the popular oil-based products such as tinctures, creams, and vapes.

We all know that oil and water don’t mix well. This reality makes things a bit tricky for CBD and other oil-soluble plant extracts because most products and supplements we use are not oil-based.

What most people don’t know is that CBD, in its natural oil form, can only be effectively incorporated into the body through a narrow range of uses. Common oil-based delivery methods, like tinctures, are not meant to be swallowed, and for good reason.

It all comes down something known as bioavailability, which indicates how much of any given substance is actually able to be absorbed by the body. There’s one bodily process in particular that’s responsible for preventing the effective uptake of CBD oil in the stomach.

First Pass Metabolism

First-pass metabolism (also referred to as the first-pass effect) is a physiological phenomena in drug (plant extract) delivery science where the concentration of a compound is greatly reduced before it reaches systemic circulation.

This concentration reduction means a decrease in bioavailability, and is a relatively common problem that affects a huge range of compounds including, morphine, curcumin (from turmeric), lidocaine, nitroglycerin, and many found in cannabis.

CBD can’t effectively make it through hepatic portal vein system when swallowed in it’s natural oil state.

First-pass metabolism only affects the bioavailability of CBD when consumed orally, and there are some creative chemistry techniques used to get around it.

Luckily, rubbing CBD into your skin, dropping some tincture under your tongue, or hitting a vape pen allows the CBD to directly enter systemic circulation. These delivery methods don’t go near any of the mechanisms associated with the first-pass effect, and bioavailability is not negatively affected.

What’s the problem?

The issue still remains that we cannot effectively absorb CBD when swallowed in it’s natural oil state.

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You might be thinking, “What about all the CBD capsules and drinks out there? Am I not actually getting the full dose that’s advertised?” The answer to those questions all depend on the method used to formulate the CBD extract.

As we learned above, the first pass effect greatly decreases the bioavailability of CBD oil when swallowed. So, unfortunately, nearly all CBD-oil capsules that you see on the market will have very poor absorption rates. That translates to taking a 20mg capsule and only actually absorbing around 5mg!

Luckily, brilliant scientists have already addressed this problem and have devised ways to effectively overcome the first pass effect.

They’ve developed novel chemistry techniques that are now common in drug delivery science and are super important because almost 40% of new drug compounds are hydrophobic and have the same oral bioavailability issues as CBD. [source]

Enter Water-Soluble CBD…

One of the primary ways to overcome the first-pass effect is to convert the naturally oil-soluble CBD extract into a water-soluble form. This makes total sense, especially when considering the fact that the average adult is somewhere from 50–60% water.

WE ARE WATER | Photo by Amritanshu Sikdar

So how does this happen? Well, the technique that we use at UnCanny Wellness is known as Self-Emulsifying Drug Delivery System [SEDDS], and possesses unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. [source]

Basically, you can think of CBD extract in oil form is a big blob (very scientific, I know). When this blob of oil enters your stomach it’s too large to pass through your gut lining and enter systemic circulation without being broken down by enzymes and passed along the the liver for processing.

By converting the oil to a water-soluble powder, the oil-blob is broken down into tiny, micro-sized pieces. These pieces of oil are very, very small, and are encapsulated within other non-toxic materials to ensure they remain stable in this new form. The end result of this process is an off-white, water-soluble, micro-encapsulated, full-spectrum, CBD hemp extract.

This conversion process completely overcomes the first-pass effect, and allows CBD oil (and other similar compounds) to be consumed orally without sacrificing bioavailability.

Why should you care?

Converting CBD oil to a water-soluble powder greatly increases the ways in which it can be used. Not everyone wants to hold a tincture under their tongue or hit a vape pen in order to get their dose of CBD.

When we take a look what’s on the shelves of health and wellness aisles in natural food stores, we can see that there are an overwhelmingly large amount of capsules and drink-powders. Only by converting CBD oil into a water-soluble powder can we effectively incorporate CBD into these types of products.

Water-soluble CBD powder opens up a world of possibilities. Not only does it allow us to effectively use capsules as a form of precise CBD delivery, but it also lets us use CBD in any drink or food product we can imagine.

CBD & Coffee — a lovely combination | Photo by Wu Yi

Want to infuse CBD into your pasta sauce? Sure.

How about throwing some CBD into that latte? No problem at all.

CBD in your smoothie? Done deal.

As you can see, water-soluble CBD powder has endless potential. It makes the most sense for widespread adoption and use in our everyday lives. Sure, you could just drop some CBD oil into any of the examples above. But how much would you actually be absorbing? Not much at all…

It would be like paying for a full tank of gas and only getting 10–20%. That’s simply unacceptable.

In Conclusion

Supplementing your wellness routine with a powerful plant compound like CBD does not need to be a chore. As a species, we’ve grown up with the cannabis plant, and hemp has played such an important role in our history.

We all contain an incredibly complex and important endocannabinoid system in our body that helps to regulate the function of our nervous and immune systems. Activating this system with CBD supplementation is something that nearly everyone can benefit from.

It’s time to start firing that system up with water-soluble CBD !

New Study Suggests Water-Soluble Cannabidiol Products Provide Best CBD Absorption

A recent study by researchers affiliated with Colorado State University has found that water-soluble cannabidiol products provide the best absorption of CBD, shedding new light on best practices for consumers seeking the benefits of the popular cannabinoid. The study, which was published last month in the peer-reviewed journal Nutrients, also explored the effects that cannabidiol has on digestion and determined that CBD products are best consumed with food for maximum absorption, among other findings.

The research, which was conducted in conjunction with Colorado State University’s Department of Health and Exercise Science, compared the absorption of five different CBD formulations in 14 male test subjects. Products studied included CBD diluted in medium-chain triglycerides (MCT) coconut oil, CBD isolate, and three different water-soluble CBD ingredients. The goal of the study was to document how each of these formulations of CBD entered and left the bloodstream and at what rate. Additionally, the study profiled how the formulations interacted with liver functionality and if there was evidence that food intake and metabolism were affected by the products.

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New research shows that taking water-soluble cannabidiol products with food provided the best . [+] absorption of CBD.

Water-Soluble CBD Had Best Absorption

The study found that water-soluble CBD preparations displayed superior pharmacokinetics compared to oil-based CBD. One of the water-soluble CBD preparations used in the study was created using proprietary technology from NextEvo Naturals, which has proven to significantly improve bioavailability. John McDonagh, CEO of the company, said that the research sheds new light on how consumers can get the most out of the CBD products they take.

“While the potential health benefits of CBD have been widely publicized, this new data suggests consumers should be very aware of the pharmacokinetic differences between commercial CBD formulations, for example, how the CBD you are taking gets absorbed into the body,” McDonagh said in a statement from NextEvo. “We set out to prove that our product formulations may actually be able to offer the many benefits of CBD because they enter the bloodstream quickly and efficiently.”

The results of the study, which NextEvo notes have not been evaluated by the U.S. Food and Drug Administration, show a more than 500% variance in maximum blood concentration achieved between water-soluble CBD ingredients compared to oil-based formulations and unformulated CBD isolate. The variance represents a significant difference in the body’s ability to absorb and process CBD, which is necessary to reap the potential health and wellness benefits of the cannabinoid.

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Taking CBD With Food Increases Absorption

The results also showed that consuming water-soluble CBD with food greatly increases the body’s absorption of CBD and modifies early insulin and triglyceride responses. Six hours after consumption, CBD concentration in the bloodstream was three times higher when consumed with food compared to taking the product after fasting. David Chernoff, MD, chief medical officer at NextEvo, says that the research revealed CBD’s potential positive effect on insulin and triglyceride levels.

“Our study results show that within 30 minutes after eating a meal, CBD appeared to lower insulin and triglyceride levels. The exact mechanism of how CBD impacts insulin levels and triglyceride levels is unclear as the CBD levels 30 min post-meal are very low,” Chernoff writes in an email. “What one can infer from these findings is that CBD may have a favorable effect on how fats and sugars are metabolized after a meal so CBD might be beneficial for supporting healthy glucose and lipid metabolism.”

Researchers have long debated if eating a meal or fasting could affect CBD’s absorption into the bloodstream. Some have found that it helps to eat when taking oil-soluble CBD, but the new research suggests that taking water-soluble CBD products with food will provide the most benefit.

“We’ve found that the best way for consumers to take CBD is in a product containing a water-soluble formulation with a meal. This allows the body the opportunity for maximum absorption into the bloodstream,” writes Chernoff. “The more CBD the body absorbs, the more likely the consumer is to experience CBD’s potential benefits.”

CBD is available in a variety of product formulations.

“This is one of the first studies to examine the potential benefits CBD has on digestion and whether it should be administered with food,” NextEvo wrote in a statement about the research. “The study provides significant evidence that consuming CBD with food alters the dynamics of CBD metabolism and increases systemic availability, favorably modifying early insulin and triglyceride responses.”

The research also revealed new evidence on the safety of CBD. The study showed that CBD taken at average doses, in this case, 30mg per dose, does not evoke physiologically relevant changes in markers of liver function, suggesting that CBD probably does not represent a risk to the liver.

Potential limitations of the study identified by the researchers include a small sample size and the fact that all test subjects were male, although the authors wrote that they “have no reason to suspect the potential for sex differences.”

A report on the study, “Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function,” was published online by the journal Nutrients in May.

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