CBD, CBG, CBN & CBC Explained A mature cannabis plant contains hundreds of different compounds which can be further divided into categories of either flavonoids, terpenes, or cannabinoids, with CBG vs CBD: Detailed Breakdown and Best Products Learn what cannabigerol is, and how CBG and CBD differ. Discover potential therapeutic effects of CBG vs. CBD, including current research studies.
CBD, CBG, CBN & CBC Explained
A mature cannabis plant contains hundreds of different compounds which can be further divided into categories of either flavonoids, terpenes, or cannabinoids, with each of these having different properties and effects on the human body. Two of the most prevalent compounds in medical marijuana are THC and CBD, with THC causing the intoxicating “high” that many people attribute to marijuana use.
Cannabidiol (CBD) is derived directly from the hemp plant, which is a cousin of the marijuana plant. It does not cause an intoxicating “high” like THC does, and according to the World Health Organization, it “exhibits no effects indicative of any abuse or dependence potential. To date, there is no evidence of public health-related problems associated with the use of pure CBD.” Several benefits of CBD use include:
- Pain & inflammation reduction
- Anxiety reduction
- Sleep benefits
- Seizure reduction
While CBD has grown to be the most popular non-intoxicating cannabinoid in recent years, there are also several similar compounds which exist that have shown to benefit the human body as well.
Cannabigerol (CBG) is a non-intoxicating cannabinoid similar to CBD, though this compound interacts with your body through very different mechanisms than CBD. Initial research has indicated that CBG acts as an agonist of the CB1 and CB2 receptors without causing any intoxicating effects. CBG may also act as a GABA reuptake inhibitor. This means that CBG may have a relationship with both neuropathic pain and inflammatory pain. The main benefits attained through use of CBG include:
- Digestive benefits
- Antibacterial benefits
- Pain & inflammation reduction
Cannabinol (CBN) is currently only attainable by deriving it from CBD through a chemical conversion. While more structurally similar to THC than CBD once it reaches its final form, CBN lacks the psychoactive effects of THC which could allow more patients to utilize it without fear of intoxication or impairment. Some of the potential benefits of CBN include:
- Antibacterial benefits
- Sleep benefits
Cannabichromene (CBC) is “newer” to the cannabinoid scene as far as research is concerned, but has shown great potential as a medical supplement thus far. While its effects feel very similar to CBD when ingested, the chemical structure of the CBC is unique and offers it the capability to affect the body in a different way than CBD. So far, research has linked CBC with the following medical benefits:
- Cancer benefits
- Analgesic benefits
At Remedy Pain Solutions, we strive to provide our patients as many natural treatment options as possible, including these compounds we have been discussing in this article. We have a full line of organic, medical-grade CBD products that are available for our patients at our Marina Del Rey office location. If you are suffering from pain and inflammation, schedule an appointment with one of our specialists at Remedy Pain Solutions to discuss what natural options might be available to treat your symptoms so you can return to pain-free life.
CBG vs CBD: Detailed Breakdown and Best Products
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CBD and THC are definitely two of the most well-known cannabinoids. CBD is known for its calming, therapeutic effects while THC is famous for its psychoactive effects that cause feelings of euphoria and sometimes confusion. While CBD and THC have both had plenty of time in the spotlight, lesser-known cannabinoids, such as CBG, are capturing interest from consumers and scientists alike.
Initial studies show that CBG may have similar characteristics of CBD. Both of these cannabinoids have no psychoactive properties. Instead, they offer antioxidant, anti-inflammatory, neuroprotective, and analgesic properties.
Here’s what you need to know about the similarities and differences between CBG and CBD. We’ll also take a look at some of the top CBD products on the market.
What is CBG?
CBG, which stands for cannabigerol, is one of more than 100 cannabinoids found in hemp and cannabis plants. Young hemp plants produce cannabigerolic acid (CBGA). As the plant matures, CBGA breaks down into cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA). These two compounds are then converted into CBD and THC. Any leftover CBGA is converted into CBG.
Even though CBG was first isolated back in 1964, the cannabinoid didn’t get a lot of attention, so there are very few studies about the compound. Modern research is in preclinical stages, but from what we know so far, CBG may have various therapeutic side effects.
It’s possible that CBG has strong pain-relieving properties that may be more effective than THC. CBG may interact with the CB1 and CB2 receptors of the endocannabinoid system, which influence inflammation, pain, and even heat sensitivity. The cannabinoid may also have antidepressant, anticancer, and antibacterial qualities.
What is CBD?
CBD, which stands for cannabidiol, naturally occurs in high concentrations in hemp and cannabis plants. CBD was first isolated all the way back in the 1930s but was mostly put aside until the 1970s when scientists determined it may be an effective anti-convulsant.
Over the years, research has confirmed many of the therapeutic benefits that CBD offers, including anti-anxiety, pain-relieving, anti-nausea, and sedative qualities. CBD has also shown to be an effective treatment for severe forms of childhood epilepsy and is used in an FDA approved drug, Epidiolex.
Over the last few years, CBD has become the cannabinoid of choice, not only for the many therapeutic benefits it offers, but also because it has no psychoactive properties. Unlike THC, CBD offers pain relief and other benefits without the risk of paranoia, anxiety, or impaired cognitive function.
Like CBG, CBD interacts with the CB1 and CB2 receptors.
Differences Between CBG & CBD
Though they offer very similar therapeutic properties, CBG and CBD do have some differences. For example, the two cannabinoids have different molecular structures. This means that the arrangement of carbon, hydrogen, and oxygen is different. Molecular structure impacts how the cannabinoid binds with receptors and also impacts bioavailability.
CBG and CBD are also unique in how they activate receptors. One study looked at how CBG and CBD interact with the 5-HT1A serotonin receptor . CBG behaves as an antagonist at that receptor, where CBD has strong anti-nausea effects, which means it acts like an agonist.
So even though the two cannabinoids are similar, when bound to the same place, they have opposing effects on this specific receptor.
CBG and CBD differ in how they stimulate the appetite. A study conducted on rats found that CBG encouraged the animals to eat two times their normal food intake. But, a study conducted on CBD found that the cannabinoid significantly reduces total food intake .
Therapeutic Benefits of CBG vs CBD
There isn’t a lot of research that has delved into the therapeutic effects of CBG. However, preclinical studies offer a little bit of insight as to how the cannabinoid may interact with the body. Like CBD, CBG doesn’t have any psychoactive properties. Instead, it offers other therapeutic benefits, including:
● Potential treatment for MRSA bacterial infections
As interest in CBG continues to grow, we can expect to learn more about the cannabinoid over the next few years. The hope is that more clinical studies and research will be conducted so that we can get a better understanding of the benefits that CBG offers.
CBD is in a similar situation, but there are far more studies that have been conducted. Research has found that CBD offers a host of therapeutic benefits, including:
● Lowered stress and anxiety
But as with any cannabinoid, there is always more to learn. Most studies have been conducted on animals, so human trials are crucial to fully understand how CBG and CBD interact in the body.
Are you interested in trying CBD, CBG, or maybe a product that contains both? Here are some of the best hemp-derived products available on the market today.
Top 4 CBD Products
Penguin is another top brand that we highly recommend. They offer some of the purest and most potent CBD products on the markets. With a well-rounded selection of products, you’re sure to find the CBD that best meets your lifestyle needs. Choose from gummies, oils, topicals, and capsules.
Penguin only uses the best ingredients, including broad-spectrum CBD oil that is extracted from Oregon grown hemp. Because these products contain no THC, you can enjoy peak mental performance while also enjoying the many therapeutic benefits that CBD has to offer.
What’s even better is that the brand offers some delicious flavors. Penguin’s CBD gummy worms are coated in a tangy sugar that will make your taste buds go wild. There’s also deliciously flavored CBD oil, including options such as Cookies & Cream, Citrus, Strawberry, and Mint.
2. Verma Farms
Verma Farms is one of the highest-quality CBD brands that we’ve found. All of their products are made with top notch ingredients that are organic and all natural. They offer an extensive collection of items to choose from, including gummies, oils, capsules, topicals, and even tropical dried fruit!
Verma Farms uses broad spectrum extract, which contains all of the wellness-boosting plant compounds, with the exception of THC. This means you can enjoy the benefits of minor cannabinoids, terpenes, flavonoids, and fatty acids!
This is a brand that takes a Hawaiian approach to making CBD. All of their products are influenced by the islands, so you can drift off to your own tropical paradise.
3. BATCH CBD
Organically grown and highly effective, BATCH CBD’s products are deeply therapeutic and create lasting benefits for both the body and the mind. Whether you are seeking a better night’s sleep, a way to ease day-to-day stress, or a natural approach to relieve pain and inflammation, BATCH has got you covered.
BATCH CBD prioritizes product quality and customer service to deliver truly life-changing results. From seed to shelf, the BATCH team carefully manages every aspect of their product development, ensuring that each and every product is sustainably crafted with ingredients of the highest quality.
BATCH has an incredible line of CBD products, including their CBG Oil , which includes a 1:1 CBD to CBG ratio . Made with a vegan formula and flavored with citrus extracts, BATCH’s CBG Oil tastes great and offers the substantive benefits of both CBD and CBG!
4. Colorado Botanicals
Colorado Botanicals once again makes our top spot. Despite years of product innovation from its competitors – they stay ahead of the curve with superior quality and some of the most potent CBD oils, capsules, topicals, and gummies on the market.
Initially offering broad-spectrum CBD extracts, Colorado Botanicals recently added full-spectrum CBD oils and several CBG products enhanced with a clinically studied curcumin ingredient and Boswellia. With so much variety and customizability, there’s something for every health-conscious shopper.
Colorado Botanicals is unique in that they can naturally retain terpenes and flavonoids thanks to their proprietary extraction and purification process. The end product is a highly pure and concentrated product without any impurities. Also, their products are constantly tested for contaminants such as heavy metals, pesticides, solvents, and microbes.
5. Extract Labs
Extract Labs is known for providing the purest, highest-quality CBD products at the lowest price, a promise which is made possible by keeping every step of production in-house. Few companies offer CBG products because it is difficult to extract and not as abundant as CBD. Extract Labs offer an extensive collection of CBG products, including full spectrum CBG oil, a THC free CBG tincture, CBG isolate, CBG softgel capsules and CBG gummies. CBG gummies are one of their most popular products, with 33mg CBG and 33mg CBD apiece – they are made with natural ingredients and quality broad spectrum hemp oil. They also have a vast array of high-quality CBD products to try.
6. Joy Organics’ USDA Certified Organic CBG and CBD Tincture
Joy Organics is one of the first CBD oil tinctures on the market to be made entirely of USDA Certified Organic ingredients. This is a brand that doesn’t compromise on quality, using only the highest quality ingredients such as broad and full spectrum CBD, along with organic MCT oil, stevia, and oil-based flavoring.
Joy Organics continues to expand its USDA Certified Organic CBD tinctures with their new CBG and CBD tincture. Their CBG + CBD Tincture contains two hemp-derived compounds to support homeostasis in the body. CBG is known as the “mother of all cannabinoids” and works synergistically with CBD to support mental and physical wellness.
In addition to this tincture, Joy Organics offers a wide array of both full and broad spectrum products that focus on clean and organic ingredients along with extensive lab testing for purity. These products include
Gummies (full and broad spectrum)
Delta 9 products
CBD and CBG are two similar yet unique cannabinoids. While hemp plants contain a much higher dose of CBD, CBG can also be extracted and used in all sorts of products. These two cannabinoids offer a variety of therapeutic benefits, and when combined, can provide highly effective relief that keeps you feeling your best.
CBG vs. CBD: What’s the Difference?
As our understanding of cannabis deepens, so too does our knowledge of cannabinoids. While both THC and CBD have had their moment in the spotlight, other lesser-known cannabinoids, such as CBG, are now starting to capture the interest of scientists and consumers.
Preclinical studies suggest that CBG may share many beneficial characteristics with CBD. Both CBG and CBD are non-intoxicating cannabinoids that potentially boast antioxidative, neuroprotective, and analgesic properties. When paired together, CBD and CBG may offer powerful anti-inflammatory benefits to treat neuroinflammation.
When paired together, CBD and CBG may offer powerful anti-inflammatory benefits to treat neuroinflammation. Photo by: Gina Coleman/Weedmaps
But where do the similarities between the two cannabinoids end? A deeper dive reveals that CBG is unique to CBD in many ways. Let’s explore how.
What is CBG?
CBG stands for cannabigerol. Cannabigerol is one of more than 120 cannabinoids found in cannabis, and was first isolated in 1964. Research into CBG is still at a preclinical stage, but the studies that are available suggest that it holds considerable therapeutic promise. CBG’s analgesic properties may surpass those of THC without the intoxicating hit. There’s also evidence to suggest CBG may offer anticancer, antidepressant, and antibacterial qualities.
Cannabigerolic acid (CBGA) is the chemical precursor to all of the well-known cannabinoids. As the cannabis plant matures and grows, enzymes convert CBGA into the three primary cannabinoid acids: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA).
Through decarboxylation, CBGA becomes CBG, enabling the cannabinoid to interact with the body’s cannabinoid receptors. Research suggests that CBG has a partial affinity for both the CB1 and CB2 receptors. CBG may also stimulate receptors that influence pain, inflammation, and heat sensitivity.
Research suggests that CBG has a partial affinity for both the CB1 and CB2 receptors.
CBG generally appears in low concentrations in most cannabis plants; however, breeding efforts have resulted in CBG-rich cannabis cultivars. CBG-dominant plants are known as “Type IV” cannabis. Although these cannabigerol-dominant plants aren’t yet commonplace in the consumer hemp and cannabis markets, they are actively being cultivated on a relatively large scale. Higher concentrations of CBG will render it easier to extract the cannabinoid for therapeutic use.
What is CBD?
CBD stands for cannabidiol, a cannabinoid found in high concentrations in type II (THC/CBD dominant) and Type III (CBD-dominant) cannabis and hemp plants. CBD was first isolated from cannabis in the late 1930s and then neglected until the seventies when scientists ignited an interest in its anticonvulsant properties.
CBD stands for cannabidiol, a non-intoxicating substance found in cannabis. Photo by: Gina Coleman/Weedmaps
Since then, research has confirmed that purified CBD offers a useful treatment for severe forms of childhood epilepsy. CBD may also boast anti-inflammatory, analgesic, anti-anxiety, anti-nausea, and sedative qualities.
In recent years, CBD has seized the spotlight due to the range of therapeutic benefits it offers. CBD may help mitigate some of THC’s less desirable characteristics such as anxiety, paranoia, and impaired cognitive function. Research suggests CBD teamed with THC generally provides more significant therapeutic benefits than either cannabinoid alone, a phenomenon that is called the entourage effect.
CBD acts on the endocannabinoid system through diverse physiological pathways. It has a partial affinity for both the CB1 and CB2 receptors but also binds to several other receptors that form part of the endocannabinoid system. Its mechanisms of action on the body are still not fully understood.
What is the difference between CBG and CBD?
CBG is different from CBD in several critical ways:
- Molecular structure. Cannabigerol and cannabidiol have different molecular structures. Molecular structure refers to the number and arrangement of hydrogen, carbon, and oxygen atoms that constitute a cannabinoid. Dissimilar molecular structures mean that CBD and CBG have different three-dimensional shapes, and therefore bind with the body’s cannabinoid receptors in different ways and act on the body distinctively. A cannabinoid’s molecular structure also helps determine the bioavailability of the cannabinoid, and its degree of solubility in water.
- Pharmacology. CBD and CBG also activate receptors differently. For example, a 2011 study published in Psychopharmacology compared the effects of CBD and CBG at the 5-HT1A serotonin receptor. CBD appears to exert its anti-nausea effects through its affinity for the 5-HT1A receptor, acting as an agonist (activator). CBG, on the other hand, behaves as an antagonist (blocker) at the 5-HT1A receptor. The findings showed that a pre-treatment with CBG blocked CBD’s anti-emetic effects, suggesting that the two cannabinoids bound to the same place, but had opposing actions at this receptor.
- Appetite stimulation. Another critical way in which CBG differs from CBD is in appetite stimulation. Research in rats showed that doses of CBG encouraged the animals to eat more than double their normal food intake. In another study, cannabigerol didn’t induce any changes to feeding behavior, but cannabidiol significantly reduced total food intake.
What are the therapeutic effects of CBG?
Although there are no clinical trials that have explored the effects of CBG on humans, a number of preclinical studies offer insights into some of the potential therapeutic effects of CBG. While CBG won’t offer you an intoxicating, psychoactive experience, it may provide other unique therapeutic benefits that may help with the following conditions — though more human trials are needed, of course.
- Appetite stimulation. As already discussed, preclinical studies have revealed that CBG can markedly promote appetite in rats. A 2017 study emphasized the therapeutic significance of this finding, pointing out that purified CBG may represent a novel treatment option for cachexia, appetite loss, and wasting in humans. Unlike THC, CBG can help to drive hunger without any undesirable intoxicating effects.
- MRSA bacterial infections. CBG has also demonstrated its clout as a potent antibiotic. Researchers tested the antibacterial potential of 18 different cannabinoids, including cannabigerol, against MRSA. CBG outperformed all of the cannabinoids tested and worked as well as vancomycin, a powerful antibiotic.
- Cancer. CBG boasts anticancer properties due to its ability to inhibit abnormal cell proliferation. Research has provided evidence of its anti-tumorigenic properties by inhibiting the formation of mouse skin melanoma cells.
With interest in CBG on the rise, expect to see and hear more about this unique cannabinoid both in the research lab and at your local dispensary counter.